Neurolieve Biosciences is approaching a final pre-clinical stage and has the ambition to entering into FIH study after completion of GLP toxicology study.
Neurolieve Biosciences is approaching a final pre-clinical stage and has the ambition to entering into FIH study after the completion of last non-clinical studies. Peripheral Neuropathy is a common and often debilitating neurological disorder affecting millions of people that refers to a group of conditions that involve damage to the peripheral nervous system and leads to severe discomfort that significantly deteriorates the quality of life. The complexity of neuropathic pain and its varied causes – from diabetes to chemotherapy – make it a stubborn and multifaceted health challenge.
Peripheral Neuropathy affects daily life, leading to fatigue, poor sleep, and memory disturbances. Patients and their caregivers face high costs related to medical care, medications, and lifestyle adjustments. These additional symptoms exacerbate the overall impact on patients’ well-being.
– Hypoalgesia: This occurs when a normally painful stimulus results in a decreased pain response. (For example, the pinprick should hurt but it doesn’t.)
– Dysesthesia: This refers to any unexpected sensations that feel strange, unpleasant or painful.
Causes of neuropathic pain can include:
Alcohol use disorder, Diabetes, Facial nerve conditions, HIV/AIDS, Central nervous system disorders like stroke, Parkinson’s disease and multiple sclerosis (MS), Complex regional pain syndrome, Shingles.
Other causes of neuropathic pain include:
Chemotherapy drugs (cisplatin, paclitaxel, vincristine), Radiation therapy, Amputation, which can cause phantom limb pain, Spinal nerve compression or inflammation, Trauma or surgeries with resulting nerve damage, Tumors that press on nerves.
This condition from which millions of individuals are suffering has a huge economic and social burden. Neuropathic pain is an issue because it can cause symptoms that can be constant or intermittent and can significantly impact a person’s quality of life. The pain may be present even when nothing painful is happening to the individual. It can make it hard to work and do other normal daily activities, which can lead to anxiety or depression. Furthermore, neuropathic pain tends to get worse over time.